2024
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- Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase Mamand, et. alInternational Immunopharmacologydoi: https://doi.org/10.1016/j.intimp.2024.111584
- Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniquesParot, et. al.Journal of Controlled Releasedoi: https://doi.org/10.1016/j.jconrel.2024.01.037
- A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticlesFrancia, et. al.PNASdoi: https://doi.org/10.1073/pnas.2307803120
- Endosomal escape: A bottleneck for LNP-mediated therapeuticsChatterjee, et. al.PNASdoi: https://doi.org/10.1073/pnas.2307800120
- mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyondEstape, et. al.Advanced Drug Delivery Reviewsdoi: https://doi.org/10.1016/j.addr.2024.115190
- Polyethylene glycol (PEG) as a broad applicability marker for LC–MS/MS-based biodistribution analysis of nanomedicinesHyldbakk, et. al.Journal of Controlled Releasedoi: https://doi.org/10.1016/j.jconrel.2024.01.016
2023
- Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial AdministrationZeng, et. al.ACS Nanodoi: https://doi.org/10.1021/acsnano.3c05341
- Cryo-XPS for Surface Characterization of NanomedicinesCan, et. al.The Journal of Physical Chemistry Adoi: https://doi.org/10.1021/acs.jpca.3c03879
- Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation Gupta, et. al.Cellsdoi: https://doi.org/10.3390/cells12182285
- The cellular response to extracellular vesicles is dependent on their cell source and doseHagey, et al.Science Advancesdoi: https://www.science.org/doi/10.1126/sciadv.adh1168
- Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospectsKon, et. alNature Reviews Clinical Oncologydoi: https://doi.org/10.1038/s41571-023-00811-9
- Identification of scaffold proteins for improved endogenous engineering of extracellular vesiclesZheng, et. alnature communicationsdoi: https://doi.org/10.1038/s41467-023-40453-0
- Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA–Lipid ComplexesJános Szebeni, et al.ACS Nanodoi: https://doi.org/10.1021/acsnano.2c11904
- High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profilerSych, et al.nature biotechnologydoi: https://doi.org/10.1038/s41587-023-01825-5
- Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions to PEG-containing Covid-19 vaccines: Evidence for immunogenicity of PEGKozma, et al.Vaccinedoi: https://doi.org/10.1016/j.vaccine.2023.06.009
- Surface display of functional moieties on extracellular vesicles using lipid anchorsZheng, et al.Journal of Controlled Releasedoi: https://doi.org/10.1016/j.jconrel.2023.04.033
- Physicochemical characterization and quantification of nanoplastics: applicability, limitations and complementarity of batch and fractionation methodsHuber, et. al.Analytical and Bioanalytical Chemistrydoi: https://doi.org/10.1007/s00216-023-04689-5
- Covid-19 vaccines elicit effective IgG responses in an elderly thymus cancer patient with chemotherapyAkos Koller & János SzebeniHuman Vaccines & Immunotherapeuticsdoi: https://doi.org/10.1080/21645515.2023.2188035
- A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacteriumKon, et. al.Science Advancesdoi: DOI: 10.1126/sciadv.adg1036
2022
- Principles for designing an optimal mRNA lipid nanoparticle vaccineKon, Edo, et al.Current Opinion in Biotechnologydoi: https://doi.org/10.1016/j.copbio.2021.09.016
- Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complementEstapé Senti, Mariona, et al.Journal of Controlled Releasedoi: https://doi.org/10.1016/j.jconrel.2021.11.042
- Cell-specific targeting of extracellular vesicles though engineeringthe glycocalyxZheng, et al.Journal of Extracellular Vesiclesdoi: https://doi.org/10.1002/jev2.12290
- A Bayesian implementation of Quality-by-Design for the development of Cationic Nano-Lipid for siRNA TransfectionBastogne, Thierry, et al.IEEE Transactions on NanoBiosciencedoi: https://doi.org/10.1109/tnb.2022.3213412
- The Hypertensive Effect of Amphotericin B-Containing Liposomes (Abelcet) in Mice: Dissecting the Roles of C3a and C5a Anaphylatoxins, Macrophages and ThromboxaneOrfi, et. al.Biomedicinesdoi: https://doi.org/10.3390/biomedicines10071764
- mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cellsBevers, Sanne, et al.Molecular Therapydoi: https://doi.org/10.1016/j.ymthe.2022.07.007
- A state of the art in analytical quality-by-design and perspectives in characterization of nano-enabled medicinal productsBastogne, Thierry, et al.Journal of Pharmaceutical and Biomedical Analysisdoi: https://doi.org/10.1016/j.jpba.2022.114911
- Identification of storage conditions stabilizing extracellular vesicles preparationsGörgens, André, et al.Journal of Extracellular Vesiclesdoi: https://doi.org/10.1002/jev2.12238
- Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccinesSzebeni, J., et al.Nature Nanotechnologydoi: https://doi.org/10.1038/s41565-022-01071-x
- Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeuticsVervaeke, Pieter, et al.Advanced Drug Delivery Reviewsdoi: https://doi.org/10.1016/j.addr.2022.114236
- A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factorDézsi, L., et al.GeroSciencedoi: https://doi.org/10.1007/s11357-021-00495-y
- Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticlesEvers, Martijn J.W., et al.Journal of Controlled Releasedoi: https://doi.org/10.1016/j.jconrel.2022.01.027
2021
- To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternativesShi, et. al.Advanced Drug Delivery Reviewsdoi: https://doi.org/10.1016/j.addr.2021.114079
- A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal bloodPetho, et. al.Renal Failuredoi: https://doi.org/10.1080/0886022X.2021.2007127
- Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complementEstape, et. al.Journal of Controlled Releasedoi: https://doi.org/10.1016/j.jconrel.2021.11.042
- Dosing extracellular vesiclesGupta, et. al.Advanced Drug Delivery Reviewsdoi: https://doi.org/10.1016/j.addr.2021.113961
- Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo Bazaz, et. al.Biomedicinesdoi: https://doi.org/10.3390/biomedicines9081046
- Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine StormKozma, Gergely Tibor, et al.Frontiers in Immunologydoi: https://doi.org/10.3389/fimmu.2021.642860
- Complement-mediated hypersensitivity reactions to an amphotericin B-containing lipid complex (Abelcet) in pediatric patients and anesthetized rats: Benefits of slow infusionMilosevits, Gergely, et al.Nanomedicine: Nanotechnology, Biology and Medicinedoi: https://doi.org/10.1016/j.nano.2021.102366
- Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?Vogel, Robert, et al.Journal of Extracellular Vesiclesdoi: https://doi.org/10.1002/jev2.12052
2020
- The Critical Choice of Animal Models in Nanomedicine Safety Assessment: A Lesson Learned From Hemoglobin-Based Oxygen CarriersBedocs, Peter, and Szebeni, JanosFrontiers in Immunologydoi: https://doi.org/10.3389/fimmu.2020.584966
- Paving the Road for RNA TherapeuticsDammes, Niels, and Peer, DanTrends in Pharmacological Sciencesdoi: https://doi.org/10.1016/j.tips.2020.08.004
- Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imagingGupta, Dhana, et al.Journal of Extracellular Vesiclesdoi: http://dx.doi.org/10.1080/20013078.2020.1800222
- The Biomolecular Corona of Lipid Nanoparticles for Gene TherapyFrancia, Valentina, et al.Bioconjugate Chemistrydoi: https://doi.org/10.1021/acs.bioconjchem.0c00366
- Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticalsKozma, Gergely TiborAdvanced Drug Delivery Reviewsdoi: https://doi.org/10.1016/j.addr.2020.07.024
- Extracellular vesicles as drug delivery systems: Why and how?Elsharkasy, Omnia M., et al.Advanced Drug Delivery Reviewsdoi: https://doi.org/10.1016/j.addr.2020.04.004